Featured Publications

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A standardized plant extract containing a target compound is acceptable as a potent therapeutic entity: relevance to BEC and solamargine, a topical clinical formulation CuradermBEC5.

New approaches to curb developmental and end-stage production expenses, whilst generating a safe and effective treatment for cancer, resulting in lower cost for the patient and healthcare system, are warranted. A bioassay-guided fractionation of a Solanum plant, S. sodomaeum, to a standardized extract can be classified as a new drug. It is shown that a specific standardized plant extract, BEC, containing a given concentration of a target efficacious and safe compound, solamargine, is an acceptable anticancer and less costly chemotherapeutic reality...

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Topical CuradermBEC5 Therapy for Periocular Nonmela-noma Skin Cancers: A Review of Clinical Outcomes

Approximately 5 to 10 percent of all skin cancers occur in the periocular region. Basal cell carcinoma is the most frequent malignant periocular tumor, followed by squamous cell carcinoma, sebaceous gland carcinoma, and malignant melanoma. Nonmelanoma skin tumors at the periocular area often cause disfigurement with destruction of soft conjunctival tissue. Many therapeutic methods have been recommended to combat the morbidity and mortality associated with these lesions. Excisions with frozen-section control or Mohs micrographic surgery are regarded as the gold-standard treatments...


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Drug therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents

In the last century, the discovery of cytotoxic agents was revolutionary for anticancer therapy. These therapies have resulted in better understanding of cancer in general. However, the development of agents that combine efficacy, safety and convenience remains a great challenge. The narrow, if not adverse, therapeutic index of most drugs, the damage not only to cancer cells, but also to normal and healthy tissue and the occurrence of resistance have limited anticancer efficacy. This review presents the development of promising novel cytotoxic solasodine rhamnosyl glycoside drugs that offer not only gains in specificity and efficacy, but also in safety, tolerability, non-resistance and convenience...

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Solasodine Glycosides: A Topical Therapy for Actinic Keratosis. A Single-Blind, Randomized, Placebo-Controlled, Parallel Group Study with CuradermBEC5

Untreated actinic keratosis can advance to squamous cell carcinoma, which in turn is associated with a risk of metastasis. Current treatments for actinic keratosis have many shortcomings. This communication describes the efficacy and safety of a topical cream therapy, CuradermBEC5, containing solasodine glycosides (0.005%) for actinic keratosis.Methods: Randomly assigned patients with actinic keratosis on the face, trunk or extremities received so-lasodine glycosides cream (CuradermBEC5) or placebo (vehicle) that was self-applied to the lesions...


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A Review of Solasodine Rhamnosides Therapy for in-situ squamous cell carcinoma on the Penis.

The majority of penile cancers develop from squamous cells within the skin resulting in a non-melanoma form of skin cancer, squamous cell carcinoma. Squamous cell carcinomas can develop anywhere on the penis, most appear on the foreskin in men who have not been circumcised or on the glans. Various types of squamous cell carcinomas ranging from Bowen’s disease, erythroplasia of Queyrat and Buschke-Lowenstein tumour have been identified on the penis. When detected early, these types of cancer can be successfully treated. However, the current treatment procedures have the potential for disfigurement and dysfunction of male genitalia, with associated psychological distress...

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Intralesion and CuradermBEC5 Topical Combination Therapies of Solasodine Rhamnosyl Glycosides Derived from the Eggplant or Devil’s Apple Result in Rapid Removal of Large Skin Cancers. Methods of Treatment Compared

Solasodine rhamnosyl glycosides (SRGs) are chemotherapeutic agents for the treatment of cancer. SRGs in a cream formulation, CuradermBEC5, is very effective for the treatment of nonmelanoma skin cancers with excellent cosmetic end results. Intralesion injection of SRGs successfully dispose of very large tumours in animals without any clinical adverse effects. The mode of action of SRGs is by apoptosis. In this study, it is shown that small to large basal cell...


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CuradermBEC5 for Skin Cancers, Is It? An Overview

Skin cancer incidence is increasing at alarming rates and is considered by some as an epidemic. Its incidence is higher than all other cancers combined. The developments of new treatments have not parallelled the increased incidences of this disease. A variety of treatments are available with differing outcomes. More recently a novel topical treatment, consisting of the antineoplastic compounds solasodine rhamnosyl glycosides, solamargine and solasonine, which are derived from plant material, has been described that claims to have many advantages over the currently used skin cancer therapies. This review investigates...

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Topical Solasodine Rhamnosyl Glycosides Derived From the Eggplant Treats Large Skin Cancers: Two Case Reports

Solasodine rhamnosyl glycosides (BEC) are a new class of antineoplastics that show superior efficacy than many established anticancer drugs as shown by intravenous, intraperitoneal and intralesion administrations. Previous studies have described the efficacy of BEC on nonmelanoma skin cancers by topical application. Two cases are now reported which show that BEC in a cream formulation Curaderm is very effective for the treatment of large nonmelanoma skin cancers that are considered difficult to treat by existing modalities. Moreover, the cosmetic outcomes are very impressive.

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Solasodine Rhamnosyl Glycosides in a Cream Formulation is Effective for Treating Large and Troublesome Skin Cancers

It is now established that solasodine rhamnosyl glycosides (BEC) are antineoplastics. Specificity of BEC to interact with particular receptors on tumour cells relative to normal cells and the involvement of the sugar rhamnose, conjugated to the glycoalkaloids BEC, as a key molecule to gain entry into cancer cells but not normal cells has been established. Once the BEC-receptor is inside the cell by the receptor-mediated endocytosis process, the complex is eventually taken up by the lysosomes. BEC then induces the lysosome to rupture causing immediate cancer cell death...

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Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter study

Objective: To assess the safety and efficacy of a 0.005% mixture of solasodine glycosides in the treatment of basal cell carcinoma.

Design: Double-blind, randomized, and vehicle-controlled, parallel group study.

Setting: Ten centers in the United Kingdom.

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Glycoalkaloids from Solanum sodomaeum are effective in the treatment of skin cancers in man

A cream formulation containing glycoalkaloids purified from the plant species Solanum sodomaeum L. is effective in the treatment of the malignant human skin tumours; basal cell carcinomas (BCCs), squamous cell carcinomas (SCCs) and the benign tumours; keratoses and keratoacanthomas. Histological analyses of biopsies taken before, during and after treatment give compelling evidence of the efficacy of the formulation. The treated lesions did not recur for at least 3 years after cessation of therapy. The observed complete regressions were; 20/24 for the BCCs; 5/6) for the SCCs; 23/23 for the keratoses; and, 9/9 for the keratoacanthomas. Biochemical, haematological and urinanalytical studies demonstrated that there were no adverse effects on the liver, kidneys or haematopoietic system during treatment. Normal skin treated with the formulation likewise was free from adverse histological or clinical effects. The data indicate that glycoalkaloids of this type are therefore potentially useful in the treatment of several types of human skin cancers.

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Treatment of Bowen's Disease on the Penis with Low Concentration of a Standard Mixture of Solasodine Glycosides and Liquid Nitrogen

The most common form of penile cancer is squamous cell carcinoma (SCC). Due to the high risk for lymph node metastases, penile SCC is usually treated aggressively with Mohs micrographic surgery, excision with wide margins, or penectomy. These procedures have the potential for disfigurement and dysfunction of male genitalia, with associated psychological distress. Therefore, when treating superficial BCC (Bowen's disease) of the penis, a more conservative approach is feasible and often desired by the patient. Nonsurgical treatment options include topical 5-fluorouracil, imiquimod, neodymium-doped yttrium aluminium garnet (Nd:YAG) or carbon dioxide (CO2) laser, and localized rediation. Here, we report a case of Bowen's disease of the penis successfully treated using a combination approach with a standard mixture of solasodine glycosides (BEC5) and supplemental liquid nitrogen used only on thickened, verrucous genital warts that were also present on the penis.

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