Competing Treatment Regimes

A variety of treatments such as surgical excision, curettage and electrocautery, cryotherapy, Moh’s micrographic surgery, chemotherapy, photodynamic therapy, radiotherapy, Imiquimod cream, Picato gel and CuradermBEC5 are available for either/or AKs, BCCs and SCCs.

Surgical Excision

This surgical procedure is used to treat primary and recurrent tumours. The tumour and an area of healthy looking skin (margin) around the tumour are removed surgically. The resulting wound is usually closed with stitches. Often, skin from another area of the body (skin graft), or healthy skin moved from a nearby area (skin flap) is used to complete the treatment. After surgery, the excised tissue is examined under a microscope to see if any cancer cells were present in the skin that appeared cancer free. The cure rates range from good to very bad. A limitation of this method is that this procedure in non-specific and does not distinguish between tumours and normal skin. The major shortcoming of surgical excision is the pain and discomfort and the potential for long term scarring and quality of life.

Mohs Micrographic Surgery

This specialised surgical technique removes the visible tumour first and then removal of successive layers of skin, one at a time, until microscopic examination no longer reveals cancer cells. Mohs surgery is carried out while the patient is under local anaesthesia. Removing and examining each layer takes a long time, usually over one hour. Once skin cancer is no longer visible under the microscope, the surgical wound is treated as needed and varies from stitches to covering the surgical site with skin from another area of the body (skin graft) to moving healthy skin from a nearby area to cover the surgical wound (skin flap).

Mohs surgery is a treatment for most non-melanoma skin cancers. However, the length and intensity of this surgical procedure limit its use to treating recurrent skin cancer, larger tumours, areas where it is essential to preserve as much skin as possible (such as an ear, eyelid, nose, lip or hand), tumours in which it is difficult to establish when the cancer ends, and sites prone to recurrence. This surgery when in process is non-specific and does not distinguish cancer cells from normal cells.

Curettage and Electrodesiccation

This method is used to treat small basal cell and squamous cell carcinomas in non-crucial areas such as the trunk and extremities. The procedure consists of scooping out the cancer by using a spoon-like instrument called a curette and then using an electric needle to burn or “cauterize” the remaining cancer cells and to control bleeding. The scraping and cauterizing is typically repeated 3 times, and the wound tends to heal without stitches. This procedure does not distinguish cancer cells from normal cells.

Cryotherapy

Cryotherapy is a treatment in which surface skin lesions are frozen. Liquid nitrogen is the most common method used to freeze skin lesions. Cryotherapy also known as cryosurgery is mostly used to treat solar keratoses. However, it is sometimes also used to freeze small skin cancers such as superficial basal cell and in situ superficial squamous cell carcinomas (Bowen’s disease), but this is not always successful and careful follow-up is necessary. Cryotherapy stings and may be painful. There may be immediate swelling and redness. The treated area is likely to blister within a few hours. Within a few days a scab forms and the blister gradually dries up. The blister dries to a scab. The scab peels off after 5-10 days on the face and 3 weeks on the hand. A sore or scab may persist as long as 3 months on the lower leg because healing at this site is often slow. Cryotherapy may result in a white mark (hypopigmentation) or a scar, particularly when freezing has been deep or prolonged, as is required for cancerous lesions. Skin lesions may fail to clear or may recur at a later date, necessitating further cryotherapy, surgery or other treatment. Cryotherapy is non-specific and does not distinguish between normal or abnormal skin. Whatever area on the skin the liquid nitrogen (temperature -196°C) touches, it kills.

Radiation Therapy

Radiation treatments for skin cancer are used in areas that are difficult to treat with surgery. It is used for large tumours, tumours that cover a large area, or tumours that are difficult to surgically remove because of location, such as eyelids, ears or noses. To obtain a good end result, the procedure involves many treatment sessions, usually 25-30. This procedure is non-specific and does not distinguish tumours from normal tissue.

Laser Therapy

Laser therapy may be used to vaporize superficial and multiple basal cell carcinomas and to excise or destroy squamous cell carcinoma. This therapy does not destroy cancer cells found deeper in the skin, so close follow-up with the patient is essential. This therapy is non-specific and does not distinguish tumours from normal tissue.

Topical Cream Treatment

Medical therapy using creams that contain anticancer agents (5-fluorouracil, 5-FU. Efudex, Fluoroplex) or stimulate the immune system (Imiquimod) are used to treat skin lesions. These creams are applied several times a week for several weeks or months. More recently Picato Gel has become available for the treatment of AK. All of these topical creams or gels are non-specific and produce brisk inflammation and irritation. Their limitations include discomfort, which may be severe, and a low cure rate, which makes medical treatment unsuitable for treating most skin cancers or AKs on the face. There are very significant toxic side effects with these treatments.

CuradermBEC5 Topical Cream

CuradermBEC5 therapy is advantageous over excision by demonstrating largely scar-free healing and complete eradication of the cancer cells. The treatment is very specific, killing only cancer cells, efficacious, safe and inexpensive, being a patient administered therapy. CuradermBEC5 has an exceptional safety profile, it having been established that neither the active ingredients of the drug nor their residual breakdown products enter the blood stream in quantities detectable by mass spectrometry. None of the haematological, chemical and biochemical parameters in the blood system are affected by CuradermBEC5 therapy. Local effects of use are limited to inflammation, erythema and occasionally transient burning effects. Moreover, CuradermBEC5 preferentially destroys cancer cells and can be used on substantial and sub-cutaneous neoplasms, rendering it a far superior treatment option. Finally CuradermBEC5 has a clinically proven efficacy rate of approximately 70% after eight weeks use and virtually 100% after sixteen weeks use.

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CuradermBEC5 Therapy Succeeds Where Other Therapies Fail

Patient 1: Radiation Therapy

After radiation but before CuradermBEC5 therapy showing the presence of cancer and the ineffectiveness of radiation therapy.

Patient 1: CuradermBEC5

After CuradermBEC5 therapy of the same lesion, but now, showing the successful removal of the cancer with CuradermBEC5.

Patient 2: PDT

After photodynamic therapy, but before CuradermBEC5 therapy, showing that the cancer was still present after PDT.

Patient 2: CuradermBEC5

After CuradermBEC5 therapy of the same lesion, but now, showing the successful removal of the cancer with CuradermBEC5.

Patient 3: Laser Therapy

After laser surgery, but before CuradermBEC5 therapy showing that the cancer was still present.


Patient 3: CuradermBEC5

After CuradermBEC5 therapy of the same lesion, now treated with CuradermBEC5, showing the successful removal of this lesion with CuradermBEC5.

Patient 4: Imiquimod

After treatment with Imiquimod Cream (Aldara) the cancer returned and functionality of the organ was jeopardised.

Patient 4: CuradermBEC5

CuradermBEC5 therapy of the same cancer resulted in complete removal of the cancer. The functionality of the organ was fully restored.